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MSP / MSP2-M
MULTIPLE SCLEROSIS (MS) PROFILE, SERUM AND SPINAL FLUID (CSF)

Test Code MSP / MSP2-M 
Test MULTIPLE SCLEROSIS (MS) PROFILE, SERUM AND SPINAL FLUID (CSF) 
Methodology Nephelometry and Isoelectric Focusing (IEF) with IgG Immunoblot Detection 
Description Includes CSF testing for albumin, IgG, and oligoclonal banding. Includes serum testing for albumin and IgG. Also includes CSF IgG synthesis rate, CSF IgG/albumin, serum IgG/albumin, and CSF IgG Index.

Useful for the assessment of spinal fluid proteins, including oligoclonal bands. Aids in the diagnosis of inflammatory demyelinating diseases of the central nervous system, particularly multiple sclerosis. 

Specimen BOTH SERUM AND SPINAL FLUID ARE REQUIRED FOR THIS TEST. SPINAL FLUID MUST BE OBTAINED WITHIN 1 WEEK OF SERUM DRAW.

SERUM
Draw blood in a plain, red-top tube(s) or a serum gel tube(s). Spin down and send 1.0 mL of serum refrigerated.
NOTE: Label specimen appropriately (serum).

SPINAL FLUID
1.0 mL of spinal fluid. Send specimen refrigerated.
NOTE: Label specimen appropriately (spinal fluid). 

Reference Values OLIGOCLONAL BANDS
<4 bands

CSF INDEX:
CSF IgG index: 0.00 - 0.85
CSF IgG: 0.0 - 8.1 mg/dL
CSF albumin: 0.0 - 27.0 mg/dL

Serum IgG:
0-4 months: 100-334 mg/dL
5-8 months: 164-588 mg/dL
9-14 months: 246-904 mg/dL
15-23 months: 313-1170 mg/dL
2-3 years: 295-1156 mg/dL
4-6 years: 386-1470 mg/dL
7-9 years: 462-1682 mg/dL
10-12 years: 503-1719 mg/dL
13-15 years: 509-1580 mg/dL
16-17 years: 487-1327 mg/dL
> or =18 years: 767-1590 mg/dL

Serum albumin: 3,200-4,800 mg/dL
CSF IgG/albumin: 0.0-0.21
Serum IgG/albumin: 0.0-0.4
CSF IgG synthesis rate: 0-12 mg/24 h 

Analytic Time 2 Days 
Day(s) Test Set Up Monday through Saturday 
CPT Code(s) 82040  Albumin, serum
82042  Albumin, CSF
82784 x 2  IgG (serum and CSF)
83916  Oligoclonal band, spinal fluid
83916  Oligoclonal band, serum