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ZYG-M
ZYGOSITY TESTING (MULTIPLE BIRTHS)

Test Code ZYG-M 
Test ZYGOSITY TESTING (MULTIPLE BIRTHS) 
Methodology Polymerase Chain Reaction (PCR)
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.) 
Description Useful for determining genetic risk for an individual whose twin/triplet is affected with a genetic disorder for which a specific genetic test is not availoble, for assessment of risks prenatally when one fetus of multiples is known to be affected by a specific disorder, for organ or bone marrow transplantation compatibility testing, and for familial/parental interest 
Specimen All specimens should include a "Molecular Genetics Congenital Disorders request Form" with information including relevant clinical and family history information.
SPECIMEN MUST ARRIVE WITHIN 96 HOURS OF DRAW.

SUBMIT ONLY 1 OF THE FOLLOWING SPECIMENS:

BLOOD
Draw a lavender-top (EDTA) tube or a yellow-top (ACD) tube of whole blood and send 3.0 mL (minimum: 0.2 mL) in the original VACUTAINER®. Invert several times to mix blood. Forward unprocessed whole blood promptly at ambient temperature only.

PRENATAL SPECIMENS
All prenatal specimens must be accompanied by a maternal blood specimen.

AMNIOTIC FLUID
Obtain 20 mL (minimum: 10 mL) of amniotic fluid. Transfer specimen to 2 screw-capped, sterile centrifuge tubes. Send specimen refrigerated. SPECIMEN CANNOT BE FROZEN. A separate culture charge will be assessed under test #80334 "Amniotic Fluid Culture for Genetic Testing" unless a chromosome analysis on the specimen is also being performed at NorDx. Alternatively, we will accept 2 T-25 flasks of confluent cultured cells from another laboratory sent at ambient temperature.

CHORIONIC VILLUS
Obtain 20 mg (minimum: 5 mg) of chorionic villus specimen, refrigerated in a 15 mL tube of transport medium. A separate culture charge will be assessed under test #80333 "Fibroblast Culature for Genetic Tsting" unless a chromosome analysis on the specimen is also being performed at NorDx. Alternatively, we will accept 2 T-25 flasks of confluent cultured cells from another laboratory sent at ambient temperature. 

Reference Values An interpretive report will be issued. 
Analytic Time 14 Days 
Day(s) Test Set Up Monday 
CPT Code(s) 81265