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PFRBC / PPFE-M
PROTOPORPHYRINS, FRACTIONATION, ERYTHROCYTES

Test Code PFRBC / PPFE-M 
Test PROTOPORPHYRINS, FRACTIONATION, ERYTHROCYTES 
Methodology High-Performance Liquid Chromatography (HPLC) with Fluorescence Detection 
Description
Useful for establishing a differential diagnosis of erythropoietic protoporphyria, X-linked dominant protoporphyria, iron-deficiency anemia, and chronic lead intoxication.

Includes separate quantitation of zinc protoporphyrins and free protoporphyrins. 

Specimen Whole Blood to be Washed at Mayo Medical Laboratories:
Specimen must arrive within 48 hours of draw. If specimen cannot arrive within 48 hours, please send washed erythrocytes and include the cell suspension information (see Mayo test #31891 Protoporphyrins, Fractionation, Washed Erythrocytes.)

1. Patient should abstain from alcohol for 24 hours.
NOTE: Include a list of medications the patient is currently taking and forward with the specimen.
2. Draw a full, green-top (sodium heparin) tube, and place on wet ice immediately. A dark blue top (metal free heparin) or green top (lithium heparin) tube is also acceptable.
3. Send entire heparinized whole blood specimen refrigerated. SPECIMEN CANNOT BE FROZEN.
4. Test will be cancelled if frozen whole blood is received. 

Reference Values FREE PROTOPORPHYRIN
<20g/dL packed cells

ZINC-COMPLEXED PROTOPORPHYRIN
<60 g/dL packed cells

See "Porphyrinogens, Porphyrins, and Porphyrias". 

Analytic Time 2 Days 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 82492  

Special Instructions