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APP53
P53, IMMUNOHISTOCHEMISTRY STAIN

Test Code APP53 
Test P53, IMMUNOHISTOCHEMISTRY STAIN 
Description P53 protein is a tumor suppressor gene product. The normal (wild type) variant of P53 acts to suppress uncontrolled proliferations of cells and to decrease the probability of malignant transformation. Point mutations of the P53 gene result in a mutant form of P53 protein with a dysfunctional structure and an increased half life. Mutant P53 accumulation has been detected in breast, lung, colon, stomach, bladder, and testicular carcinoma's. Overexpression of P53 in breast carcinoma has been shown to be a strong indicator of recurrence and to correlate with poor prognosis. Overexpression of the P53 oncogene has been implicated as the most common genetic alteration in the development of human malignancies.

NOTE: This test is usually ordered in conjunction with a pathology consultation. The pathology professional component will be billed separate by the consulting pathologist. 

Specimen Formalin-fixed or paraffin-embedded tissue specimen. 
Reference Values An interpretive report will be issued. 
Analytic Time 2 Days 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 88342