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APCYCD1
CYCLIN D-1 IMMUNOHISTOCHEMISTRY STAIN

Test Code APCYCD1 
Test CYCLIN D-1 IMMUNOHISTOCHEMISTRY STAIN 
Description Cyclin D-1 is a key cell cycle regulator that works with specific protein kinases to regulate the entry of cells in S-phase. The proto-oncogene encoding Cyclin D-1 is frequently amplified in a wide range of human malignancies. Mantle cell lymphoma is characterized by the translocation of the bcl-1 gene resulting in over expression of Cyclin D-1. The Cyclin D-1 antibody is useful for distinguishing mantle cell lymphomas (84% positive) from other lymphomas with a similar morphology, which are negative.

NOTE: This test is usually ordered in conjunction with a pathology consultation. The pathology professional component will be billed separately by the consulting pathologist. 

Specimen Formalin-fixed or paraffin-embedded tissue specimen 
Reference Values An interpretive report will be issued. 
Analytic Time 2 Days 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 88342