|Test||CD68 / MACROPHAGE (KP1), IMMUNOHISTOCHEMISTRY STAIN|
|Description||KP1 antibody (CD68) reacts with tangible macrophages, interdigitating macrophages of lymph nodes and tissue macrophages from various sources such as Kupffer cells of the liver and alveolar macrophages of the lung. It also stains peripheral blood monocytes and granulocytes, myeloid precursors, mast cells, and osteoclasts. KP1 stains a cell population known as "plasmacytoid T cells" which are present in many reactive lymph nodes. This antibody may be useful for the identificaton of myelomonocytic and histiocytic malignancies. It may also help distinguish malignant fibrohistiocytoma from other pleomorphic sarcomas. KP1 has been shown to stain a variable number of cells in malignant melanomas. Neoplasms of lymphoid origin are usually negative, although some B-cell neoplasms such as small lymphocytic lymphoma and hairy cell leukemia may show weak granular staining of the cytoplasm.
NOTE: This test is usually ordered in conjunction with a pathology consultation. The pathology professional component will be billed separately by the consulting pathologist.
|Specimen||Formalin-fixed or paraffin-embedded tissue specimen.|
|Reference Values||An interpretive report will be issued.|
|Analytic Time||2 Days|
|Day(s) Test Set Up||Monday through Friday|