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CRYOS / CRGSP-M
CRYOGLOBULIN + CRYOFIBRINOGEN

Test Code CRYOS / CRGSP-M 
Test CRYOGLOBULIN + CRYOFIBRINOGEN 
Methodology Quantitation Qualitative Typing by Precipitation
Immunofixation, if indicated 
Description If Cryoglobulin has a result other than negative, Immunofixation will be performed at an additional charge. 
Specimen Plasma and serum are required for this test.

Plasma for Cryofibrinogen
1. Draw blood in a lavender-top (EDTA) tube(s). (Plasma gel tube is not acceptable.) Tube(s) must remain at 37 degrees C.
2. Centrifuge at 37 degrees C. (Do not use a refrigerated centrifuge. If necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37 degrees C until after separation of plasma from red cells.
3. Place 1 mL (minimum 0.5mL) of EDTA plasma into an appropriately labeled plastic vial.
4. Send specimen refrigerated.

Note: Label specimen appropriately (plasma).

Serum for Cryoglobulin
1. Draw blood in a plain, red-top tube(s). (Serum gel tube is not
acceptable.) Tube(s) must remain at 37 degrees C.
2. Allow blood to clot at 37 degrees C.
3. Centrifuge at 37 degrees C. (Do not use a refrigerated centrifuge. If necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37 degrees C until after separation of serum from red cells.
4. Place 5 mL (minimum 3mL) of serum into an appropriately labeled plastic vial.
5. Send specimen refrigerated.

Note: 1. Analysis cannot be performed with <3 mL of serum. Smaller volumes are insufficient to detect clinically important Trace (mixed) cryoglobulins. Less than 3 mL will require draw of a new specimen.
2. Label specimen appropriately (serum). 

Reference Values CRYOGLOBULIN
Negative (positives reported as percent)
If positive after 1 or 7 days, immunotyping of the cryoprecipitate
is performed at an additional charge.
CRYOFIBRINOGEN
Negative
Quantitation and immunotyping will not be performed on
positive cryofibrinogen. 
Analytic Time 2 days 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 82585  Cryofibrinogen
82595  Cryoglobulin
86334  Immunofixation (if indicated)