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CLLF/ CLLF-M
CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) FISH

Test Code CLLF/ CLLF-M 
Test CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) FISH 
Methodology Fluorescence In Situ Hybridization (FISH) 
Description Useful for:

Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with chronic lymphocytic leukemia (CLL)

Identifying and tracking known chromosome abnormalities in patients with CLL and tracking response to therapy

Distinguishing patients with 11;14 translocations who have leukemic phase of mantle cell lymphoma from patients who have CLL

Detecting patients with atypical CLL or other forms of lymphoma associated with translocations between IGH and BCL2, BCL3, MYC, or other partner genes 

Specimen Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

Submit only 1 of the following specimens:

Specimen Type: Blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 7-10 mL (minimum 2 mL)
Collection Instructions:
1. Invert several times to mix blood.
2. Other anticoagulants are not recommended and are harmful to the viability of the cells.

Specimen Type: Bone marrow
Container/Tube: Green top (sodium heparin)
Specimen Volume: 1-2 mL (minimum 1 mL)
Collection Instructions:
1. Invert several times to mix bone marrow.
2. Other anticoagulants are not recommended and are harmful to the viability of the cells.

Forms: If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request Form (T726) with the specimen
http://www.mayomedicallaboratories.com/it- files/hematopathology-request-form.pdf 

Reference Values An interpretive report will be provided 
Analytic Time 7 to 10 Days 
Day(s) Test Set Up Samples processed Monday through Sunday. Results reported Monday through Friday, 8 a.m.-5 p.m. CST. 
CPT Code(s) 88271x1  DNA probe, each; coverage for sets containing 3 probes (if appropriate)
88271x2  DNA probe, each; coverage for sets containing 4 probes (if appropriate)
88271x2  DNA Probe, each; each additional probe set (if appropriate)
88271x3  DNA probe, each; coverage for sets containing 5 probes (if appropriate)
88274  Interphase in situ hybridization, 25 to 99 cells, each probe set (if appropriate)
88275  Interphase in situ hybridization, 100 to 300 cells, each probe set (if appropriate)
88291  Interpretation and report