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HCVFS / 550123L
HEPATITIS C VIRUS FIBROSURE

Test Code HCVFS / 550123L 
Test HEPATITIS C VIRUS FIBROSURE 
Methodology See component analytes for methodologies. 
Description Useful for: Assessment of liver status following a diagnosis of HCV. Baseline determination of liver status before initiating HCV therapy. Posttreatment assessment of liver status six months after completion of therapy. Noninvasive assessment of liver status in patients who are at increased risk of complications from a liver biopsy. 
Specimen Draw blood in either a red-top tube or serum gel tube following at least an 8hr fast. Spin down and send 3 mL (2.5 mL in first tube and 0.5 mL in second tube) of serum.Patient age and sex must be included on the test request form. Send specimens refrigerated.

NOTE: If specimen pick-up will be greater than 72hrs freeze both serum specimens. 

Reference Values Alanine aminotransferase (ALT): male: 0-55 IU/L; female: 0-40 IU/L
a2-Macroglobulin: 110-276 mg/dL
Apolipoprotein A-1: male: 110-180 mg/dL; female: 110-205 mg/dL
Bilirubin, total: 0.1-1.2 mg/dL
y-Glutamyl transferase (GT): male: 0-65 IU/L, female: 0-60 IU/L
Haptoglobin: 34-200 mg/dL

Metavir scale:
Fibrosis stage (Fibro test):
F0 - no fibrosis: 0.00-0.21
F0-F1: 0.21-0.27
F1 - portal fibrosis: 0.27-0.31
F1-F2: 0.31-0.48
F2 - bridging fibrosis with few septa: 0.48-0.58
F3 - bridging fibrosis with many septa: 0.58-0.72
F3-F4: 0.72-0.74
F4 - cirrhosis: 0.74-1.00

Activity grade (ActiTest):
A0 - no activity: 0.00-0.17
A0-A1: 0.17-0.29
A1 - minimal activity: 0.29-0.36
A1-A2: 0.36-0.52
A2 - moderate activity: 0.52-0.60
A2-A3: 0.60-0.63
A3 - severe activity: 0.63-1.00 

Analytic Time 7 Days from receipt of specimen 
Day(s) Test Set Up Monday through Saturday 
CPT Code(s) 82172  Assay of apolipoprotein
82247  Bilirubin total
82977  Assay of GGT
83010  Assay of Haptoglobin Quant
83883  Assay of Nephelometry not specified
84460  Alanine amino (ALT) (SGPT)