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AFPSM / MAFP-M
AFP SINGLE MARKER SCRN, MATERNAL, SERUM

Test Code AFPSM / MAFP-M 
Test AFP SINGLE MARKER SCRN, MATERNAL, SERUM 
Methodology Two-site Immunoenzymatic (Sandwich) Assay 
Description Useful for prenatal screening for open neural tube defect. 
Specimen Draw blood in a plain, red-top or serum gel tube. Spin down and send 1.0mL of maternal serum refrigerated in a plastic, screw capped vial.

NOTE:
1. The following information is required for processing:
A. Maternal date of birth (not age), weight, race, and number of
fetuses
Note: Clinical Interpretation is not possible if 3 or more
fetuses are present.
B. Is patient an insulin-dependent diabetic?
C. Gestational age calculation (provide at least 1of the following):
1. Date of ultrasound and gestation by ultrasound on the
date ultrasound was performed.
Note: Do not extrapolate to draw date. Twin
pregnancies must have ultrasound information
included.
2. First day of last menstrual period (LMP)
3. Gestation by physical exam
4. Expected date of delivery, must specify by LMP or
ultrasound.

2. Gestational age must be between 15 and 22 weeks for neural
tube interpretation; 16 to 18 weeks is optimal.
3. Please complete and submit a "Second Trimester
AlphaFetoprotein Maternal Serum/Quad Screening Patient
Information Sheet" and forward it with the specimen. 

Reference Values Neural Tube Defects
An AFP multiple of the median (MoM) < 2.5 is reported as screen negative. AFP MoMs>= 2.5 (singleton pregnancies) and >= 5.33 (twin gestation) are reported as screen positive.

An interpretive report will be provided.
Screen-positive results are called back to ordering client. 

Analytic Time 1 Day 
Day(s) Test Set Up Monday through Saturday 
CPT Code(s) 82105