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VH-M
VMA AND HVA, RANDOM U

Test Code VH-M 
Test VMA and HVA, Random U 
Methodology Liquid Chromatography-Tandem Mass Spectrometry
(LC-MS/MS) 
Description First preferred test for screening for catecholamine-secreting tumors in a random urine specimen when requesting both homovanillic acid and vanillylmandelic acid
Supporting a diagnosis of neuroblastoma
Monitoring patients with a treated neuroblastoma 
Specimen 10 mL from a random urine collection. Adjust urine pH to 1.0 to 5.0 with 50% acetic or HCl acid. Send specimen refrigerated in a plastic, 13-mL urine tube.

NOTE:
1. Patient's age is required on request form for processing.
2. Administration of L-dopa may falsely increase homovanillic acid and vanillylmandelic acid results; it should be discontinued 24 hours prior to and during collection of specimen. 

Reference Values VMA
<1 year: <25.0 mg/g creatinine
1 year: <22.5 mg/g creatinine
2-4 years: <16.0 mg/g creatinine
5-9 years: <12.0 mg/g creatinine
10-14 years: <8.0 mg/g creatinine
> or =15 years: <7.0 mg/g creatinine

HVA
<1 year: <35.0 mg/g creatinine
1 year: <30.0 mg/g creatinine
2-4 years: <25.0 mg/g creatinine
5-9 years: <15.0 mg/g creatinine
10-14 years: <9.0 mg/g creatinine
> or =15 years: <8.0 mg/g creatinine 
Analytic Time 2 Days 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 83150  HVA
84585  VMA

Special Instructions