Test Code PBNP 
Methodology Electrochemiluminescence Immunoassay 
Description A test designed to aid in the diagnosis and assessment of disease severity in congestive heart failure (CHF), plus risk stratification in acute coronary syndromes (ACS).

No sample should be collected on patients receiving therapy with high biotin doses(i.e. biotin therapy for Multiple Sclerosis or oncology patients; skin, hair and nail supplements, or multivitamins containing > 5 mg/day) until at least 12 hours after the last biotin administration. If unsure, or if the clinical picture does not fit the results please contact the laboratory . We have methods to check for biotin interference as well as for any other interferences and for the accuracy of the results.

Biotin interference would falsely decrease the result of this assay. 

Specimen Draw blood in a Lithium Heparin pst gel tube (preferred) or a serum gel tube (acceptable). Spin down and send 2mL plasma or serum. (0.5 mL minimum) refrigerated. 
Reference Values Age <50 years: 0 - 450 pg/mL
Age 50-75 years: 0 - 900 pg/mL
Age >75 years: 0 - 1800 pg/mL

NT-proBNP levels of <300 pg/mL are associated
with a negative predictive value of 98% for excluding
heart failure. NT-proBNP levels may be lower in obese individuals. NT-proBNP levels increase with renal failure and optimal cut-off values for diagnosing heart failure have not been clearly established
- 1200 pg/mL is suggested by the literature. 

Analytic Time 1 Day - Available STAT 
Day(s) Test Set Up Monday through Sunday 
CPT Code(s) 83880