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AMITR / AMT-M
AMITRIPTYLINE AND NORTRIPTYLINE, S

Test Code AMITR / AMT-M 
Test AMITRIPTYLINE AND NORTRIPTYLINE, S 
Methodology High-Performance Liquid Chromatography (HPLC) 
Description Useful for monitoring the adequacy of blood concentration during Amitriptyline therapy. The test may also be useful to evaluate patient compliance. 
Specimen Draw blood in a plain, red-top tube. (SERUM GEL TUBE IS NOT ACCEPTABLE.) Spin down and send 2.0 mL (minimum 1.0 mL) of serum refrigerated. 
Reference Values AMITRIPTYLINE and NORTRIPTYLINE
Total therapeutic concentration: 80 - 200 ng/mL
Total toxic concentration: > or = 300 ng/mL

NORTRIPTYLINE ONLY
Therapeutic concentration: 70 - 170 ng/mL
Toxic concentration: > or = 300 ng/mL

Note: Therapeutic ranges are for specimens drawn at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens. 

Analytic Time 1 Day 
Day(s) Test Set Up Monday through Sunday 
CPT Code(s) 80335  
G0480 or  G0481 or G0482 or G0483, Drug test(s), definitive (Government payers, if appropriate), if indicated