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ALPHA / APGH-M
ALPHA-SUBUNIT PITUITARY TUMOR MARKER

Test Code ALPHA / APGH-M 
Test ALPHA-SUBUNIT PITUITARY TUMOR MARKER 
Methodology Immunochemiluminescent assay (ICMA) 
Description Quantitating the a-sunbunit has been advocated as a monitoring test to detect the recurrence of tumors in patients who have undergone resection of pituitary adenomas. 
Specimen Draw blood in either a plain, red-top tube or serum gel tube. Spin down and send 1.0 mL (minimum 0.35 mL) of serum FROZEN in plastic vial on dry ice. Refrigerated specimen is acceptable if received within 7 days from time of draw. 
Reference Values Pediatric:
< or = 5 days: < or = 50 ng/mL
6 days - 12 weeks: < or = 10 ng/mL
3 months - 17 years: < or = 1.2 ng/mL

Tanner II -IV*: < or = 1.2 ng/mL

Adults:
Males: < or = 0.5 ng/mL

Premenopausal females: < or = 1.2 ng/mL
Postmenopausal females: < or = 1.8 ng/mL

Pediatric and adult reference values based on Mayo studies.

*Puberty onset (transition from Tanner stage I to Tanner stage II)
occurs for boys at a median age of 11.5 (+/-2) years, and for girls at a median age of 10.5 (+/-2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African-American girls. For boys, there is no proven relationship between puberty onset and body weight, or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18. 

Analytic Time 1 Day 
Day(s) Test Set Up Thursday 
CPT Code(s) 83520