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TELOU / NTXPR-M
N-TELOPEPTIDES, URINE

Test Code TELOU / NTXPR-M 
Test N-TELOPEPTIDES, URINE 
Methodology Vitros ECi Competitive Assay
Rate Jaffe 
Description Useful for identifying individuals with elevated bone resorption, who have osteoporosis in whom response to treatment is being monitored; for predicting response (as assessed by bone mass measurements) to FDA-approved anti-resorptive therapy in postmenopausal women; and for assessing effectiveness of osteoporosis treatment including FDA-approved anti-resorptive therapies in postmenopausal women, individuals with osteoporosis, Paget's disease of bone, and anti-estrogen or selective estrogen therapies.

NOTE: This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policy "Collagen Crosslinks, Any Method". Please verify that the diagnosis code (ICD-9) you have chosen demonstrates medical necessity for the test as documented in the physician's patient record. The CMS web site or the NorDx Medical Necessity Reference Guide are available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD-9 code chosen or if the frequency of a frequency-limited test is unknown. 

Specimen SUBMIT ONLY 1 OF THE FOLLOWING:

24-HOUR URINE
4.0 mL (minimum: 0.5 mL) from a 24-hour urine collection. No preservative. (Boric acid and toluene are acceptable). See "Urine Preservatives" for multiple collections. Refrigerate specimen during collection. Send specimen frozen in a plastic tube.
NOTES:
1. Indicate 24-hour collection on the specimen container.
2. 24-hour volume is required on request form for processing.
3. The addition of preservative or application of temperature
controls (refrigeration) MUST OCCUR WITHIN 4
HOURS OF COMPLETION OF COLLECTION.
4. Follow "Urine Collection" instructions.

SECOND-MORNING VOIDED (2-HOUR) URINE
4 mL (minimum: 0.5 mL) from a second-morning voided urine collection. Send specimen refrigerated in a plastic tube.
NOTES:
1. Indicate second-voided (2-hour) collection on the specimen
container.
2. Specimen MUST BE REFRIGERATED WITHIN
4 HOURS OF COLLECTION.
3. Follow "Urine Collection" instructions.

RANDOM URINE
4 mL (minimum: 0.5 mL) from a random urine collection. Send specimen frozen in a plastic tube.
NOTES:
1. Indicate random collection on the specimen container.
2. Specimen MUST BE REFRIGERATED WITHIN
4 HOURS OF COLLECTION.
3. Follow "Urine Collection" instructions. 

Reference Values All units are reported in nmol NTx/mmol creatinine
Males:
<6 years: 576-1763
> or =6 years-14 years: 307-1367
> or =14 years-18 years: 102-1048
> or =18 years: 21-66

Females:
<6 years: 576-1763
> or =6 years-14 years: 307-1367
> or =14 years-18 years: 55-378
> or =18 years: 19-63

Based on Mayo in-house studies of 75 children and adolescents age 3.5 to 18.5, and >100 adults. 

Analytic Time 1 Day 
Day(s) Test Set Up Sunday through Friday 
CPT Code(s) 82523  

Special Instructions