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ESTRN / E1-M
ESTRONE

Test Code ESTRN / E1-M 
Test ESTRONE 
Methodology High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) 
Description Useful for determination of circulating levels of estrone with no or minimal cross reactivity with other estrogens. This test may be useful in detecting a drug's suppression activity of amomatase, which converts androgens to estrogens via estrone, and may serve as an additional parameter confirming estradiol results. Estrone may be used in the diagnosis of polycystic ovarian syndrome.

NOTE: This test is intended for adult patients only. For pediatric patients, please order ESTRONE, PEDIATRIC, SERUM (500172E). 

Specimen Draw blood in a plain, red-top tube. Spin down and send 1.2 mL of serum refrigerated in a screw-capped, plastic vial.
Serum must be separated from cells within 24 hours of draw. 
Reference Values Children*
1 - 14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.

Males
Tanner Stage (Mean Age) Reference Range
Stage I#: (7.1) undetectable - 16 pg/mL
(>14 days and prepubertal)
Stage II: (11.5) undetectable - 22 pg/mL
Stage III: (13.6) 10 - 25 pg/mL
Stage IV: (15.1) 10 - 46 pg/mL
Stage V: (18) 10 - 60 pg/mL

#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

Females
Tanner Stages (Mean Age) Reference Range
Stage I#: (7.1) undetectable - 29 pg/mL
(>14 days and prepubertal)
Stage II: (10.5) 10 - 33 pg/mL
Stage III: (11.6) 15 - 43 pg/mL
Stage IV: (12.3) 16 - 77 pg/mL
Stage V: (14.5) 17 - 200 pg/mL

#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African-American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

*The reference ranges for children are based on the published
literature (1,2), cross-correlation of our assay with assays used to
generate the literature data and on our data for young adults.

Adults
Males 10 - 60 pg/mL

Females

Premenopausal: 17 - 200 pg/mL
Postmenopausal: 7 - 40 pg/mL

Conversion factor:
E1: pg/mL x 3.704 = pmol/L (molecular wt = 270) 

Analytic Time 1 Day 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 82679