|Test||PRENATAL ANEUPOIDY DETECTION, FLUORESCENCE IN SITU HYBRIDIZATION (FISH)|
|Methodology||Fluorescence In Situ Hybridization (FISH)|
|Description||Standard chromosome analysis takes about 7 - 9 days for culture, harvest, and analysis for amniotic fluid cells. In cases of medical urgency, FISH analysis can be used to detect chromosome aneusomy of 13, 18, 21, X, and Y within 24 hours (processing time of 6 hours) from uncultured amniotic fluid cells.
NOTE: This test, when ordered on Medicare patients, is subject to the CMS Medicare Coverage Issues Manual (MCIM) Diagnostic Services policy "Cytogenetic Studies". Please verify that the diagnosis code (ICD-9) you have chosen demonstrates medical necessity for the test as documented in the physician's patient record. The CMS web site or the NorDx Limited Coverage Documentation Guide are available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD-9 code chosen.
|Specimen||NOTE: Please complete a Cytogenetics/AFP Congenital Disorders Request Form and forward it with the specimen.
SUBMIT ONLY 1 OF THE FOLLOWING SPECIMENS:
|Reference Values||An interpretive report is provided.|
|Analytic Time||1 - 2 Days|
|Day(s) Test Set Up||Monday through Sunday|
88271 x 5 DNA probe, each
88275 Interphase in situ hybridization
88291 Interpretation and report