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GM1B/GM1B-M
GANGLIOSIDE ANTIBODY PANEL

Test Code GM1B/GM1B-M 
Test GANGLIOSIDE ANTIBODY PANEL 
Methodology Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) 
Description Useful for supporting diagnosis of neurological diseases - primarily motor neuron disease and motor neuropathies. 
Specimen Draw blood in either plain, red-top tube(s) or serum gel tube(s). Spin down and send 1.0 mL (minimum: 0.5 mL) of serum FROZEN in a screw-capped, plastic vial. 
Reference Values 99% of the normals fall below this titer:
IgG monosialo GM1: < 1:500
IgM monosialo GM1: < 1:1,000
IgG asialo GM1: < 1:4,000
IgM asialo GM1: < 1:4,000
IgG disialo GD1b: < 1:1,000
IgM disialo GD1b: < 1:1,000
This represents a normal result.

BORDERLINE RANGES
IgG Monosialo GM1 =1:1,000
IGM Monosialo GM1 =1:2,000
IgG Asialo GM1 =1:8,000
IgM Asialo GM1 No borderline range (normal < or = 4,000)
IgG Disialo GD1b No borderline range (normal < or = 1,000)
IgM Disialo GD1b No borderline range (normal < or = 1,000)

There is a borderline elevation of titers against ganglioside epitopes. This may be seen in patients with motor neuron disease or motor neuropathy.

ABNORMAL RESULTS
IgG Monosialo GM1 >1:1,000
IGM Monosialo GM1 >1:2,000
IgG Asialo GM1 >1:8,000
IgM Asialo GM1 >1:4,000 IgG Disialo GD1b >1:1,000 IgM Disialo GD1b >1:1,000

The ganglioside antibody titers are elevated. This is usually only seen in patients with multifocal motor neuropathy or motor variant of chronic inflammatory polyradiculoneuropathy. 

Analytic Time 3 - 7 Days 
Day(s) Test Set Up Monday, Wednesday; 5 p.m. 
CPT Code(s) 83520 x 6