|Test||MyoD1, IMMUNOHISTOCHEMISTRY STAIN|
|Description||MyoD1 immunostaining has been demonstrated in the majority of rhabdomyosarcomas various histological subtypes. Results of a recent study by Wang et al suggest that MyoD1 expression in rhabdomyosarcomas is inversely related to the degree of cellular differentiation of the tumor cells. Nuclear expression of MyoD1 has been demonstrated in other tumors, including ectomesenchymoma and a subset of Wilm's tumors. Cytoplasmic immunoreactivity with monoclonal anti-MyoD1 has been reported in rhabdomyosarcomas, neuroblastomas, Ewing's sarcomas and alveolar soft part sarcomas. However, only nuclear staining should be considered as evidence of skeletal myogenic differentiation.
NOTE: This test is usually ordered in conjunction with a pathology consultation. The pathology professional component will be billed separately by the consulting pathologist.
|Specimen||Formalin-fixed or paraffin-embedded tissue specimen.|
|Reference Values||An interpretive report will be issued.|
|Analytic Time||2 Days|
|Day(s) Test Set Up||Monday through Friday|