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APTTF-1
TTF-1, IMMUNOHISTOCHEMISTRY STAIN

Test Code APTTF-1 
Test TTF-1, IMMUNOHISTOCHEMISTRY STAIN 
Description NORMAL TISSUES
Anti-RRF-1 has been shown to be immunoreactive with Type II cells and Clara cells of the lung and follicular cells from thyroid, but was unreactive with all other normal tissues examined. The following tissues were found to lack TTF-1 expression: pituitary, prostate, testes, adrenal gland, skin, breast, kidney, colon, liver, pancreas, small intestine, brain and stomach.

ABNORMAL TISSUES
TTF-1 expression has been demonstrated by IHC in neoplastic cells derived from tumors of the lung and thyroid. Anti-TTF-1 was found to react positively with the majority of pulmonary small cell carcinomas and primary and metastatic pulmonary adenocarcinomas. A smaller proportion of large cell undifferentiated lung carcinomas (26%) were immunoreactive, whereas no immunostaining has been observed in squamous cell carcinomas of the lung. TTF-1 immunoreactivity was demonstrated in the majority of pulmonary atypical carcinoids but was rare in typical carcinoids. TTF-1 has also been detected in (3/3) thyroid papillary carcinomas. TTF-1 expression was not found in the majority of the other tumors tested such as primary breast carcinomas, breast carcinomas metastatic to the lung, renal cell carcinomas, primary and metastatic colon and prostate adenocarcinomas, and malignant mesothelimoas. When using a polyclonal antibody to TTF-1 some focal immunoreactivity was observed in 1/66 gastric adenocarcinomas and 1/8 endometrial adenocarcinomas.

NOTE: This test is usually ordered in conjunction with a pathology consultation. The pathology professional component will be billed separately by the consulting pathologist. 

Specimen Formalin-fixed or paraffin-embedded tissue specimen. 
Reference Values An interpretive report will be issued. 
Analytic Time 2 Days 
Day(s) Test Set Up Monday through Friday 
CPT Code(s) 88342